Any update on this yet?
May 7 2020
Apr 29 2020
@ All, they just rolled out an update (hotfix) which also inlcudes the following: "Tweaked: "Old Man" saves could grow massively and should now do so less for new play-throughs (we hope to also provide an experimental fix to those with broken saves in another branch)". Hopefully this permanently fixed the problems for new playthroughs! I will backup my current save and start over. THen when the other update comes (which should be compatible with the old saves) i might pick up those again. If you try it out maybe share your experiences here?
Apr 20 2020
@Wulf maybe also have a look at the follwing ticket: https://feedback.bistudio.com/T150081 its pretty much a duplicate, but a lot more people have the same problem. this tickets also has the crash reports, error logs and saves attached.
Hope this will help you in resolving the issue.
Apr 19 2020
Same problem for me! I was really enjoying playing the game but we should be able to finish it, and not be held back by crashes after 10 hours into the game. Hope this gets resolved!