Same thing happens with me. I use the Shift key bound to "Up" and, since the 0.51 update, it hasn't been working. If I have a weapon in my hands then it works properly.

It is a very rare bug. It has only happened to me a few times.

Most recently it happened when I was chasing somebody and they ran through some doors that were closed for me. When I tried opening the door, it stayed closed and made the sound effect of the door closing. I clicked on it again and then the door opened.