When chambering a single bullet into the .22 Amphibia, or when loading the magnum, I have had the game tell me the guns are loaded, but then won't shoot. I was able to make the .22 Amphibia fire by unloading the bullet and reloading a new one in repeatedly until it finally started working. I believe it can be triggered by loading a bullet into the gun while walking.
Edit: Also, in the interim there, I logged out and then in, but it was also broken upon logging in again, and was fixed while still then logged in.