I have this weird issue where the lighting/shadows outside will flicker when my mouse passes a point around the center of the screen. The shadows pretty much disappear and everything lights when my mouse is at that point on the screen. I actually recorded a video of it since it is kind of hard to describe accurately...
http://www.youtube.com/watch?v=PfHJ9DFx6Cc&feature=youtu.be
I have played other games such as Planetside 2, Bioshock:Infinite, Elder Scrolls:Oblivion(heavily modded), and I haven't seen any graphical problems in those game.
I've also attempted to mess with my video settings in game, and haven't been able to make the problem go away. It is not related to vertical sync or ambient occlusion settings. If I adjust shadow detail it also has no effect.