Despite the fact that handcuffs can usually be broken out of given enough time through struggling, there seems to be random occurrences where you are unable to break free from them. This is despite the state of the handcuffs; pristine or ruined.
I would have assumed this to be a feature, however, after a certain period of time it does become possible to use items from the inventory although you are still kept in the restraint animation.
Possible crossover with reported issue: 0002178