This started to happen after I updated to 1.42. At least I never noticed this before.
I have two profiles, one for myself and one for my fiance. I just noticed that after I made some changes to my own and her profile and try to switch to the other profile everything I click in the main menu either does not respond, or opens up with quite some delay. Some times even the PLAY menu totally disappeared. Exiting the game and running it again however fixes this.
Switching between profiles without making any changes to them seems to work alright though.