I've been having system issues since updating 1.22

The only common scenario is when you Alt-Tab out of the game.

After Alt-Tabbing the mouse click is no longer responsive.

The only fix I've found for this is to Alt-F4 out of the game AND launcher.

I'm guessing this is related to the Fullscreen bug that came with 1.22
The bug where the mouse is not bound to the game when viewing your inventory even though the game is set to full screen, fullscreen functions as if it's in Windowed mode.