During Game Launch, the Game instantly crashes.

"Engine Initialization Error"
"Please check log file for more information: ..."

In the Log the following is reported:

15:22:22:584 RENDER    (W): Adapter 0 (AMD Radeon RX 6900 XT) failed to provide some output
15:22:22:584 RENDER    (E): Couldn't build device list for any adapter.
15:22:22:584 ENGINE    (E): Failed to initialize Enfusion engine
15:22:22:584 ENGINE    (E): Unable to initialize Enfusion

I use a Zisworks X28 screen, Which relies on a dual input of DisplayPorts to put out 4k120hz. This was never an issue in any games as well as UE5 developing. Switching to Single Input 4k60 fixes the Issue.
You Plug 2 DP cables into the GPU, Both carry one side of the Screen and it gets combined inside of the TCON. The Software shouldnt have any issue with it whatsoever as the Combining is handled by the Firmware.
If you check MonitorInfoView it will be reported as a 1920x2160 screen, Windows and any other application will see it as a normal 4k screen.