Hot keys don't work. Pressing them 2 or 3 times has no effect, and neither does putting an item into a hot key slot or your hands.
Middle mouse button stops working for opening/closing doors.
Function keys don't work for Sitting, Saluting etc.

Turning the game off, verifying installation files, restarting the game doesn't do anything or help. Can last a very long time (i gave up waiting after 5 - 10 minutes).