Play game on Altis or Stratis (Stratis causes the lockup to occur much later, but it will eventually happen when many Units are on the map.), with few or no units, the game will begin to stutter up even when static after about an hour of play-time.
This is especially true when background programs are running (music, browser, gfx-manipulation program. Latter two are especially memory heavy, but when building missions I like to have the tutorials on hand.)
The total failure by the gfx card is very difficult to reproduce, it shows no pattern aside from that arma 3 needs to have been started at least once to occur. After testing no other game seems to reproduce this error, despite arma 3 being easiest on the card in terms of heat strain.