I uninstalled and reinstalled several times, I am not spamming the mouse button I am holding it down. If I spam the LMB stops working almost immediately.
This really wasn't an issue for me except for the last 8-10 days or so.
I have not changed the settings, in fact I tried to reassign the fire button after an episode but no joy.
I know this is a duplicate but I am attaching my DxDiag file, hope that helps.