Possible causes (will test tomorrow) I am running in WinXP mode, which may cause some weird permission problems, but I would not expect the game has any reason to try to access the A: drive anyway.
I also had previously tweaked some minor settings, like max frames, etc. May check to see if defaulting has an affect.
Finally, I will try and uninstall and reinstall.
Will also try to record a video if possible.