I have 3 monitors, 2 video cards. One card is a cheap on I use just for web browsing on my left monitor. The right two monitors are used on my good video card. GTX 550ti

I play in full screen. When I exit the game it moves my left monitor to the center. Sometimes it will make my left monitor the primary display.

Every time I exit I need to go back in and shuffle the monitors around back to the correct arrangement.