When running in triple-head 5760x1080 full-screen mode, then alt-tabbing to the Windows desktop and back into Arma, the frame rate drops significantly (half, in my case). The only way to get the frame rate back up is to restart Arma.
I tested in single-monitor mode, and the frame rate remains constant in this case - it only seems to be when in triple-head mode that the frame rate drops.