My friend and I will mess around in Kamy for only a few hours every couple of days. Our hands get bugged so frequently that it's game breaking. After having to collectively relog over a dozen times in a 3 hour session due to this, we commonly go to great lengths to not pick anything up, or put anything in our hands. We've gotten bugged by doing as little as dropping ammo for each other.
Trying to shoot someone attacking me, or use a melee weapon on an infected, and not having the thing in my hand that I think I do is ruining the game.