When the HUD is disabled, prompts for interaction are missing. Since it is impossible to know whether the action you will perform is to "take" or "activate" some items due to their inconsistency, it might be best to have the interaction prompts a separate toggle. It is truly more immersive to not see the prompts, but in some instances the default action is inconsistent and therefore players may accidentally perform an unintended action since the only indicator for the intended action is presented through the HUD.