There was a couple weird things going on right before this happened.

I found a magnum, put it in my pack and attempted to load it with a speedloader, when I dropped the speedloader over the magnum, the box for the reloader turned green instead of orange. Don't know if it actually loaded or not.

My hotkeys were all missing and the boxes were barely showing. Went to drop my freshly "loaded" magnum onto what I believe was the 3 slot when my game crashed.

Complete crash, unable to ctrl+alt+delete or a hard shutdown using power button. Windows would not load after forcing a power off. couldn't repair or go back to a previous state, had to reinstall Windows entirely.