In addition to classical electrophysiological methodology, Creative Bioarray offers ex vivo test systems based on Microelectrode Array (MEA) recordings in order to analyze complex drug effects on ion channel interactions and cell signaling in cellular networks including stem-cell derived approaches, tissue slices and isolated organs.
A [[ https://acroscell.creative-bioarray.com/multi-electrode-array-mea.html | Multi-Electrode Array ]] is an array made of microscopic metal electrodes (10-30 μm of diameter) distributed on a small surface area (~0.8-6 mm²). They are either regularly distributed or can be arranged to match closely the spatial organization of the tissue investigated. In neuroscience research, these small electrodes (coated with an inert and biocompatible metal) are used for recording electrical signals related to neuronal activities within the slice. MEA recordings allow mid-throughput testing capabilities for compound screening and profiling. The MEA technology enables parallel and multi-site extra-cellular recordings within a single brain slice and provides an exceptional macroscopic view of neuronal networks.